9月15日，欧洲化学品管理署(ECHA)网站公布最新提起脊椎动物实验征询的34种化学物质。这一批物质的征询截止时间是10月31日。
根据REACH法规，物质制造商及进口商有义务了解其制造或进口物质毒性反应相关的信息。ECHA为这些物质的危害属性做出评估并确保物质的危害风险得到备案，使物质的生产、制造、使用和废旧处理都得到有效控制。REACH法规同样要求涉及脊椎动物实验的物质新测试方案应只作为最后诉诸办法。
REACH法规第40（2）条规定，为最大化利用现有信息，特别是关于现有脊椎动物实验的信息，ECHA将所有脊椎动物测试方案，主要为法规附件IX和附件X要求的数据节点公布在ECHA官方网站，以征求公众评论意见。每一测试方案公布后，第三方机构有45天的评议征询时间，向ECHA提出“关于此测试方案的物质及危害节点有效信息或研究”。
34种测试方案征询物质如下表所示：
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物质身份 |
提案危害节点 |
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物质名称 |
CAS号 |
EC号 |
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tris(2,5,8,11-tetraoxatridecyl) orthoborate ||注: testing proposed with with_B-TEGME (CAS 30989-05-0, EC 250-418-4) |
161907-80-8 |
310-290-3 |
亚慢性毒性(90天): 经口 |
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生殖毒性(胚胎发育毒性) |
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生殖毒性(二代生殖毒性) |
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Slimes and Sludges, blast furnace and steelmaking |
65996-73-8 |
266-006-2 |
体内遗传毒性 |
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生殖毒性(胚胎发育毒性) |
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生殖毒性(二代生殖毒性) |
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1,6-bis(2,3-epoxypropoxy)hexane |
16096-31-4 |
240-260-4 |
亚慢性毒性(90天): 经皮 |
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生殖毒性(胚胎发育毒性) |
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生殖毒性(二代生殖毒性) |
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orthoboric acid, compound with 2-aminoethanol |
26038-87-9 |
247-421-8 |
生殖毒性(胚胎发育毒性) |
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生殖毒性(二代生殖毒性) |
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鸟类长期毒性或生殖毒性 |
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Reaction mass of p-mentha-1,4-diene and p-mentha-1,3-diene and dipentene and p-mentha-1(7),2-diene and p-mentha-1,4(8)-diene |
931-893-3 |
生殖毒性(胚胎发育毒性) |
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生殖毒性(二代生殖毒性) |
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tetrapropylenebenzene |
25265-78-5 |
246-772-4 |
亚慢性毒性(90天): 经口 |
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生殖毒性(二代生殖毒性) |
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benzyldimethylamine |
103-83-3 |
203-149-1 |
生殖毒性(胚胎发育毒性) |
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2,4,6,8-tetramethylcyclotetrasiloxane |
2370-88-9 |
219-137-4 |
亚慢性毒性(90天): 吸入 |
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生殖毒性(胚胎发育毒性) |
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生殖毒性(二代生殖毒性) |
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Coconut oil, reaction products with polyethylene glycol and trimethylolpropane |
640-964-5 |
体内遗传毒性 |
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亚慢性毒性(90天): 经口 |
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生殖毒性(胚胎发育毒性) |
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Hydrocarbons, C9-unsaturated, polymerized || Note: testing proposed with phenol, methylstyrenated EC 270-966-8 |
615-276-3 |
生殖毒性(胚胎发育毒性) |
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生殖毒性(二代生殖毒性) |
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Paraffins (petroleum), normal C>10 || Note: testing proposed with C9-C14 aliphatic solvents, 2-25% aromatics (HSPA) |
64771-71-7 |
265-232-9 |
生殖毒性(二代生殖毒性) |
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Reaction mass of 1,3-Propanediamine, N-[3-(tridecyloxy)propyl]-, branched and 1,3-Propanediamine, N-[3-(tridecyloxy)propyl]-, branched acetate |
931-295-2 |
亚慢性毒性(90天): 经口 |
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生殖毒性(胚胎发育毒性) |
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生殖毒性(二代生殖毒性) |
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Reaction mass of Bis(1,2,2,6,6-pentamethyl-4-piperidyl) sebacate and Methyl 1,2,2,6,6-pentamethyl-4-piperidyl sebacate |
915-687-0 |
体内遗传毒性 |
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Cashew, nutshell liq. |
8007-24-7 |
232-355-4 |
亚慢性毒性(90天): 经口 |
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生殖毒性(胚胎发育毒性) |
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生殖毒性(二代生殖毒性) |
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水生生物累积/沉淀 |
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dichloromethylbenzene |
29797-40-8 |
249-854-8 |
生殖毒性(胚胎发育毒性) |
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Amides, fatty acids C18 unsat, reaction products with polyethylene amines || Note: testing proposed with Tall oil diethylenetriamine imidazoline (CAS 68442-97-7) |
1226892-50-7 |
629-735-0 |
亚慢性毒性(90天): 经口 |
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生殖毒性(胚胎发育毒性) |
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Amides, Fatty acids C18 unsaturated, reaction products with tetraethylenepentamine || Note: testing proposed with Tall oil diethylenetriamine imidazoline (CAS 68442-97-7) |
1225197-81-8 |
630-459-8 |
亚慢性毒性(90天): 经口 |
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生殖毒性(胚胎发育毒性) |
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Fatty acids C18 unsat, reaction products with Pentaethylenehexamine || Note: testing proposed with Tall oil diethylenetriamine imidazoline (CAS 68442-97-7) |
629-732-4 |
亚慢性毒性(90天): 经口 |
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生殖毒性(胚胎发育毒性) |
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Fatty acids C18 unsat, reaction products with polyethylene amines || Note: testing proposed with Tall oil diethylenetriamine imidazoline (CAS 68442-97-7) |
629-742-9 |
亚慢性毒性(90天): 经口 |
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生殖毒性(胚胎发育毒性) |
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Fatty acids C18 unsat, reaction products with tetraethylenepentamine || Note: testing proposed with Tall oil diethylenetriamine imidazoline (CAS 68442-97-7) |
1226892-45-0 |
629-725-6 |
亚慢性毒性(90天): 经口 |
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生殖毒性(胚胎发育毒性) |
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Fatty acids C18 unsat, reaction products with triethylenetetramine || Note: testing proposed with Tall oil diethylenetriamine imidazoline (CAS 68442-97-7) |
1226892-44-9 |
629-765-4 |
亚慢性毒性(90天): 经口 |
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生殖毒性(胚胎发育毒性) |
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Fatty acids, C18 unsat, reaction products with diethylenetriamine || Note: testing proposed with Tall oil diethylenetriamine imidazoline (CAS 68442-97-7) |
629-715-1 |
亚慢性毒性(90天): 经口 |
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生殖毒性(胚胎发育毒性) |
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Fatty acids, C18 unsaturated, reaction product with ammonia-ethanolamine reaction by-products || Note: testing proposed with Tall oil diethylenetriamine imidazoline (CAS 68442-97-7) |
1224966-15-7 |
629-757-0 |
亚慢性毒性(90天): 经口 |
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生殖毒性(胚胎发育毒性) |
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Alkenes, C21-32 linear and branched || Note: testing proposed with oct-1-ene (CAS 111-66-0) |
931-505-2 |
生殖毒性(胚胎发育毒性) |
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生殖毒性(二代生殖毒性) |
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Alkenes, C10-14 || Note: testing proposed with oct-1-ene (CAS 111-66-0) |
85681-75-0 |
288-213-7 |
生殖毒性(胚胎发育毒性) |
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生殖毒性(二代生殖毒性) |
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Alkenes C20+ || Note: testing proposed with oct-1-ene (CAS RN 111-66-0) |
931-467-7 |
生殖毒性(胚胎发育毒性) |
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生殖毒性(二代生殖毒性) |
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Alkenes, C10-13|| Note: testing proposed with oct-1-ene (CAS RN 111-66-0) |
85535-87-1 |
287-479-1 |
生殖毒性(胚胎发育毒性) |
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生殖毒性(二代生殖毒性) |
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icos-1-ene || Note: testing proposed with oct-1-ene (CAS 111-66-0) |
3452-07-1 |
222-374-6 |
生殖毒性(胚胎发育毒性) |
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生殖毒性(二代生殖毒性) |
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Alkenes, C11-12, hydroformylation products, distn. residues |
90622-27-8 |
292-427-6 |
亚慢性毒性(90天): 经口 |
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生殖毒性(胚胎发育毒性) |
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生殖毒性(二代生殖毒性) |
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Alkenes, C13-14, hydroformylation products, distn. residues || Note: testing proposed with Alkenes, C11-12, hydroformylation products, distn. residues CAS 90622-27-8 |
90622-29-0 |
292-429-7 |
亚慢性毒性(90天): 经口 |
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生殖毒性(胚胎发育毒性) |
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生殖毒性(二代生殖毒性) |
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Alkanes, C12-26-branched and linear || Note: testing proposed with Full-range straight run gas oil |
90622-53-0 |
292-454-3 |
生殖毒性(二代生殖毒性) |
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Condensates (petroleum), vacuum tower || Note: testing proposed with Full-range straight run gas oil |
64741-49-7 |
265-049-4 |
生殖毒性(二代生殖毒性) |
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acetalization products between glucose and C20-22(even numbered)- alcohol|| Note: testing proposed with acetalization products between glucose and C16/18(even numbered)-alcohol |
923-835-0 |
亚慢性毒性(90天): 经口 |
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acetalization products between glucose and C16-18(even numbered)- alcohol |
927-870-2 |
亚慢性毒性(90天): 经口 |
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